URL Optimizing Strategies?

URL Optimizing Strategies?
URL optimization is becoming one of practices by various SEOs around the world. One of ways to optimize URL is stuffing in keywords in the URL. Is URL optimization strategy worth going for? I don't really know. But can anybody list out any other URL optimization strategies? (Apart from keyword stuffing in the URL)

IMO URL optimization is more close to the programming stuff like how easily you can handle dynamic urls through your coding. Even urls like /1/2/3.htm can rank high if there are enough backlinks to them. Also as a step further in optimization, urls should be more close to (reflects) the topic of the webpages.