The best payment methods in eCommerce offer security, convenience, and wide user acceptance. Popular options include credit/debit cards, PayPal, and digital wallets like Apple Pay and Google Pay. For global reach, Stripe, Square, and Razorpay are reliable. Offering Cash on Delivery can also attract local buyers. Choose methods based on your target audience, region, and transaction volume. Multiple payment options improve customer satisfaction and reduce cart abandonment, making them essential for eCommerce success.