I had the same issue where Outlook wouldn’t open even in Safe Mode. I tried basic fixes like ending Outlook processes and resetting the navigation pane, but nothing worked properly.

What finally helped me was using CubexSoft Outlook Export, which allowed me to access and export my mailbox data without relying on Outlook to open normally. It helped me safely extract emails, attachments, and folders from the Outlook data file when the application itself was stuck.

After that, I also repaired my Office installation, and Outlook started working again.

If Safe Mode is not opening at all, using a tool like CubexSoft Outlook Export can be a quick workaround to recover your data first, then you can troubleshoot Outlook separately.